Bioorganic & Medicinal Chemistry Letters, 26 (2016) 440-444.
Anti-inflammatory properties of quebecol and its derivatives
SÉbastien Cardinal, Jabrane Azelmat, Daniel Grenier, AND Normand Voyer
Abstract
Herein we report our results on the anti-inflammatory activity of quebecol, a polyphenolic compound discovered in maple syrup. Bioassays demonstrated that quebecol has an anti-inflammatory effect on LPS-induced NF-κB activation and inhibits the secretion of two pro-inflammatory cytokines, IL-6 and TNF-α. We also prepared and tested precursors of quebecol and its derivatives corresponding to its substructures of interest, with the aim to study the structure–activity relationships. Comparing the results obtained for all tested compounds allowed the identification of the main moiety responsible for the anti-inflammatory activity of quebecol.
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